Now
As of 1st of August, 2025
Very personal things
Back from vacation.
Plans for my parental leave are finally settled, September to January it is.
Work
Protein science, SAR driving assays, small molecules, LIMS administration.
On 24th of June, gave a talk at Discovery Europe 2025, “Leveraging coupled equilibrium in fragment screening”.
Study and projects
Thoughts about the last year’s Landrum and Riniker paper are still haunting my mind. Observable affinity is not a descriptor of the target/ligand pair alone, even if acquired with an experiment of highest excellence and technical vigor (a rare beast itself). I am a bench scientist, I know this too well.
Then, there is also a bunch of papers about kinetics to plow through, and not all of them are on covalent probes, and the papers are good. The topic is trendy yet again… it is my biggest research interest, was the main subject of my PhD - but do I think that an information-rich target-based assay strengthens a real discovery program significantly? Hurts to say, but I am not that sure…
Reading
I have a horrible habit of reading several books in parallel, primarily because I don’t want to laser focus during the evenings and weekends.
It’s a little stupid to talk about books before finishing them, but here are the books I’m reading now:
- Termination Shock by Neal Stephenson. This is my second Stepehnson’s book, I don’t think I like the author that much.
- Harry Potter och Hemligheternas Kammare - eftersom jag behöver mer övning i svenska.
- Free as in Freedom by Sam Williams. RMS biography, nuff said.
Playing
(…I started “Baldur’s Gate 3” two and a half years ago, and still haven’t finished it.)
None.
Sport
I am doing really good and consistent This is the only New Year resolution that did not fail. Few workouts per week, few 5-10K runs.
Ran a lot while on vacation, in a mountainish/hilly area of Portugal. Kilometers of elevation gains, sun, heat, felt really good. Maybe I will run the next half marathon, who knows.